T Nation

Aromasin Dosing

On 100mg of Test C a week. Just received my aromasin and looking for some dosing recommendations. I was thinking of starting 6.25 mgs EOD.

TT 676
Estrogen 42

It’s difficult to give you solid advice with a complete set of labs, SHBG would be very important since this determines how often you should be injecting.

Also most doctors order the wrong E2 labs which is designed for females, is your E2 Sensitivity LC-MS/MS? If not you will crash your E2 levels and discover a new kind of hell!

We need more info including lab ranges. Usually here we recommend 1mg AI per 100mg of T-cyp, but I would be more cautious and start out a bit lower knowing that some are over responders.

I’m on self prescribed TRT and used the Female Hormone Panel test provided
by Private labs MD. It’s my understanding that the E2 test included is not
the correct test as it is not the “sensitive” test. I’m experiencing some
high E2 symptoms and ordered some liquid Exemestane. I understand that I’m
flying blind here and that a better blood test is in order but I was hoping
on starting a low dose AI to relieve some of my symptoms. Based on this
info what would your recommendation be for dosing the Aromasin?

I would be careful and use lowest dose possible because low E2 is ten times worse the high E2. Your female E2 labs of 42 pg/mL is an exaggeration, you can’t be that far over the ranges.

So what would explain high E2 symptoms without it actually being high?

Is this what you meant? These were my symptoms 4 weeks ago, since lowering my dose they are almost completely gone.

High Estradiol Symptoms:

Soft erections, inability to maintain an erection
water retention (less frequent urination), leading to excessive sweating, blood pressure spikes or high blood pressure (from the water retention)
hot flushing (flushing around the ears or on the face)
night sweats (from estradiol lowering, causing loss of water retention)
bloating; brain fog (like your head’s in a bubble)
testicles seem smaller than usual

Yes, some. I’ve been having ED, low libido, sensitive nipples, moodiness and mild depression since starting TRT. I started TRT mainly for ED, fatigue, brain fog and my depression. All the symptoms disappeared except the ED and depression. I now have sensitive nipples, low libido and now moodiness. I was really hoping an AI would be able to provide relief. I know ultimately a more comprehensive blood test is in order. But as many can relate I’m anxious to get quick results.

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My ED isn’t fully cured yet 8 months into TRT, but getting better all the time. It’s not going to happen overnight, most guys just don’t have any patience and quit early. You’re not going to improve unless you monitor E2 levels.

I’m in it for the long haul. All your advice was greatly appreciated systemlord, thank you.

My doctor has me on 100mg test cyp a week. With no ai my estrogen gets up to 65 pg/ml and by day 6 it’s just in range at about 40 pg/ml. My doc isn’t experienced with using ais so he referred me to an Endocrinologist in 2 months so I’ve been experimenting with Pfizer aromasin to fix the issue. I have been taking 12.5mg the day after injecting 100mg test cyp. I tested Estradiol 5 days after and brought it down to 27pg/ml. So I’m thinking that’s the perfect dosage for me. Estrogen is probably in the 30s after initial administration of aromasin. I’m 27 years old. 6’1, 230lbs around 10-12% body fat. Just throwing this information out there for you guys to use as an example. Don’t tank your estrogen. 2-3 days after you take your initial injection is when test will be the highest so I take my arsomain day 2 to kill whatever estrogen has risen. With the half life of 48 hours it will continue to kill estrogen the next day when test is still at its peak and than they both start to decline together. For me I found that 12.5 mg aromasin or 1mg arimidex for every 100mg of test. The more body fat you have the more ai you will need. Keep this in mind but still get blood work after setting your initial dose. Don’t guess what you think your estrogen is.

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Are you experiencing high E2 symptoms?


You could possibly ditch the AI if you inject more frequent smaller doses as opposed to one large injection which can drive estrogen higher than it has to be…

How long after injection did you test your estrogen. If you tested the day after you injected than that’s pretty good cuz it will only get lower but if it was day 6 or 7 I would only take 12.5 the day after injection. If you checked estrogen a day after injection and it was at 40 doing 2 smaller injections would be all you need

Well you’re supposed to do labs after 6 weeks on keeping the same dosage, I tend to feel the final estrogen results sometime between 7-8 weeks even though it’s stable by week 6. There’s a lag in when you feel your estrogen increase or decrease, your estrogen may rise and you wouldn’t feel it for several days.

I inject 21mg every 2 days and it matters not when labs are done because my levels are very steady, labs shows plus or minus 6 ng/dL, Total T 496 and Total T 490. When you inject larger doses less frequently, you need more testosterone so that when levels decline, they are high enough so that you won’t notice often requiring you to shoot for higher Total T therefore increasing estrogen in the process.

If estrogen is of no consequence, large infrequent injections isn’t a problem. I tolerate aromasin much better than anastrozole, but still over-respond to both. A 1/10 aromasin drops me too low 3.5 days after taking aromasin.

i just cant understand how different this medication (AI) behaves so drastically.
for example: I was in 12,5 mg aromasin EOD first week , no TRT , and my testosterone goes up from ~660 to ~760 and E2 goes up from 60 to 70 pg/ml in 2 weeks, second week I was 25mg ED.
At least every symptom of high E2 goes away.
Edit: this night i felt cracking joints, but no pain. I guess it took me 3 weeks to have a real decrease in E2 lvls with aromasin. good luck OP

what do you mean by this @straff

I’m still trying to understand. in my case the aromasin did not have a very strong response. Or maybe the cause could be from contamination by estradiol from an external source like milk, etc.
Or I’m a heavy conveter. T-E
I discontinued the aromasin and opted for DIM, Calcium Glucarate and Resveratrol, and felt a considerable improvement in estrogen levels based on the symptoms (I will do new tests in the future). I adjusted the diet to lower the percentage of body fat as well.

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