Trivia and more trivia. +r@nt
There was a 2005 paper that took health males and monitored LH/FSH with 200mg/week T cyp. LH/FSH shut off, as one should expect, very quickly. Then monitors intratesticular testosterone [ITT] levels by fine needle aspiration. So ouch, it was not a long study. ITT is around two orders of magnitude higher that serum T levels and ITT dropped without LH. Then hCG was doses at 125, 250 and 500iu SC EOD. 250iu roughly restored normal ITT, so that is where the TRT 250iu dosing came from.
Now based on that and understanding how anastrozole works at aromatase receptors by competing with T, you can see how anastrozole cannot work with a ~ 100:1 disadvantage inside the testes. When hCG doses are too high, or high SERM doses create very high LH, there can be a lot of T-->E2 inside the tests that can take serum E2 really high and anastrozole does not do much. Docs don't get it. It takes an engineer. Also explains how the early studies with young men given 1-2 mg/day anastrozole averaged ~ 17pg/ml E2 when one might have expected E2-->zero. See it yet? The strong HPTA's of these young guys were kicking out a lot of LH and testicular T-->E2 kept E2 levels up. A bit of a mystery in some regards just the same as the hypothalamus was still seeing some E2.
Most do not really think of what an AI is and add to confusion by calling things estrogen blockers. AI reduces E2 production, but does absolutely nothing about E2 once it gets created. A SERM can block some of the effects of estrogens in selected tissues. Now introduce mindless SERM doses in typical PCT approaches. LH goes way high and T-->E2 inside the testes goes crazy. Poor boys have very high E2 levels waiting to kill the HPTA as soon as SERM clears out and liver did see that E2 and SHBG is higher waiting to bind T as T+SHBG when the HPTA is attempting to start lowering FT. Meanwhile the testes and LH receptors see a huge drop in LH from high to crippled and the how are the testes expected to respond when the LH brakes go on? Rebound hell. PCT should be creating normal LH levels so end of PCT LH is not telling the testes to slow down. And the high LH may have desensitized the LH receptors.
Some other guys here need to beat this drum. I have left notes in the stickies in this forum.
There there is the macho not needing an AI unless they get ichy nips. E2 management is very important and AI is always needed. I see guys suggesting AI doses that would fail in a TRT context. If you take 200mg T/week you need twice as much anastrozole as a guy who takes 100mg/week. Not enough lab work and no science, just guys misleading each other. The guys who survive brag about their knowledge and the weak wreck their HPTA's eventually.
On gear, E2 increases SHBG and lowers FT. However higher T depresses SHBG. So hard to know where SHBG ends up.
E2 interferes with T at T receptors and reduces anabolic effects and we know from TRT that elevated E2 can wreck mood, emotions, energy, initiative and libido. With TRT guys we try to optimize E2 to optimize on those issues and it works very well.
No one in the TRT forums ever claims to get this right without labs. But if you have been living with elevated E2, you get blind to the effects. Correcting E2 in upper 30's to lower 20's can really make guys feel like they have been reborn. With high T levels on TRT, if you then introduce anastrozole fat patterns that improved from T alone can progress to much less fat on belly and belt line. It just happens, no effort at diet changes, no exercise and no need to do dumb very low E2.
Guys with elevated, not high, E2 can be bitchy, intolerant and short tempered. Correct E2 and they are different people who may be impossible to get upset. Emotions get dry and one may be more analytical and less reactive. I think that Roid Rage is caused by E2, makes guys bitchy. Hate to see a guy pushing 300 pound of iron having PMS. Is Roid Rage a myth or do guys have a bad E2 days. I think that it is mostly a myth.
So I spend a huge amount of time trying to get things done right for the TRT guys, who as a group want to do things correctly. It is painful in this forum as most who come here come with seeds of destructive practices and notions. For the TRT guys the major problem is that almost all doctors are idiots about these things, with the caliber of understanding of some of the young wanna do a first cycle bros; in BB steroid pharma forums a lot of idiots just walk in. The BB guys who take thoughtful gear seriously can't do much about the stampede of uneducated hordes. The voice of the knowledgeable is drowned out. I do not see the old guard anymore.
OK, I feel better now.