T Nation

Arimidex and Subq vs IM Test


#1

Hi - i have been on TRT doing IM injections 50mg 3x per week since April 2017. Recently I started injecting subq Test 6/9/17 21.4 mg qd 150mg/week) in an effort to lower e2 without arimidex. My Test levels remained the same as IM until just recently ~850. But my E2 remained elevated slightly above 100 . So, I started Arimidex 0.25mg qod 7/1717. My labs just came back e2= 10, Test= 550.

Should I switch back to IM dosing?

How long should I wait to restart Arimidex and what dose of Arimidex should I go back on?

Any thoughts KSMan?

Thanks
David


#2

Out of curiosity, how do you feel? It’s subjective, and everyone is different, but I’m interested how your felt with E2 at 100 compared to 10. Also, even though T dropped to 550 do you feel any different, same, better, worse?


#3

So your Estrogen level remained the same in subQ as it did intramuscular?

I would try every monday and thursday at 50 mgs per…

You ae injecting 150 mgs per week which i think is too high.
How are your DHT levels? Any issues with prostate or hair?

Also, you seem to convert a lot to estrogen. Are you overweight or do you have belly fat?


#4

Your posts lack units!

With target of E2=22pg/ml

Assume you are E2=10pg/ml

New Arimidex dose = .25mg X [E2=10pg/ml / 22pg/ml] = 0.11mg

You need to make a solution of 1mg/ml in vodka and dispense by volume or by drops. Stop for 5 days and resume at reduced dose.

You may be making less T+SHBG which would lower TT and increase FT. I know that you are concerned that TT is lower.

How are you feeling? Did you have a short spell where you felt better as E2 was dropping. Some feel bad with low E2. Did you get E2 = 10 or E2 < 10?


#5

Thanks so much for responding KSman. Yes labs were pg/ml for e2. My e2= 10, NOT < 10.
I was starting to feel possibly less upbeat, erections were poor, libido less, but also more peaceful and less irritable more relaxed surprisingly.
I did have a short period where morning erection was very good and libido was even better (though libido for me is rarely much of an issue – even before
I started trt and my TT was 190.

I started back on IM injections yesterday 50mg MWF.
I would expect my TT to rise again to 850. So, I’m wondering if your calculation will be underestimating my dose given my TT on subq was 550 and the arimidex dose og .25mg qod
Was based on this instead of 850 where I expect to be with IM shots soon?

I have several questions about making the Arimidex solution.
First, how long is it stable for in Vodka? Ie how much solution should I make up at a time ( a month’s worth, a week’s worth?, do I need to store it in a light protective container /vial?)
Second, do I need a mortar and pestle to crush the arimidex tablets prior to adding Vodka to dissolve?
I will use an oral syringe to administer.

Thanks so much!


#6

Yes, E2 did not seem to change. Also after 6-8 weeks on subq qd dosing 150mg/week my TT fell significantly after staying steady at 850 same as IM for quite awhile.

I have been on 100mg/week Test and my levels only reached 550 which I felt was not high enough.

You are correct I do convert a lot to estrogen and I have no idea why. I do not carry a lot of fat and have more of an athletic build with not a ton of belly fat. Go figure.

I did have a body fat mass analysis done which indicates I do have a significant amount of body fat I just don’t know - is it visceral fat more than subq fat? Looking at me no one thinks I have that much fat.

My endocrinologist did say (not sure if this is correct KSman) that cosmetic liposuction of subq fat does not improve/decrease aromatization which I found strange because aromatase lives in fat. Does it just not reside in subq fat KSman???

Thanks
David


#7

Much improved with lower E2, sharper mentally - not sure about libido, erections etc because TT was lower than before and E2 was actually low. I guess I need to be in more ideal ranges before I can accurately comment.
I did not feel terrible at all with TT 550 and E2=10.

Thanks
David


#8

Anastrozole does not dissolve in water and the alcohol also means that bacterial growth is impossible. Others have not needed to grind the pills. Will be very stable and I don’t think that light is an issue, do not expose to direct sunlight.

yes, SC–>IM changes the whole game, you will need to get labs and do AI dose corrections.


#9

My endocrinologist did say (not sure if this is correct KSman) that cosmetic liposuction of subq fat does not improve/decrease aromatization which I found strange because aromatase lives in fat. Does it just not reside in subq fat KSman???

Thanks
David


#10

Yes, and also in other tissues.

How much fat removal are we talking about? There is fat under all areas of skin. What does this have to do with anything?


#11

Well, Liposuction removes subq fat - if a significant amount Is removed - and aromatase lives in this fat
It might be a way to reduce or eliminate Arimidex?

Thanks
David