T Nation

Appetite Molecule ID'd

Hungry? Scientists find appetite molecule
Agent in brain responsible for making mammals feel full
Reuters

Updated: 10:27 a.m. ET Oct 2, 2006
HONG KONG - Scientists in Japan have identified a molecule responsible for making mammals feel full, a discovery that could lead to new ways to treat obesity in humans.

Scientists believe appetite is controlled in a region of the brain called the hypothalamus, and the group of researchers claims to be the first to pinpoint an agent that triggers an increase or decrease in appetite.

In an article published on Sunday in the online version of the journal Nature, the scientists identified the molecule as nesfatin-1, which is produced naturally in the brain.

After injecting the molecule into the brains of rats, the scientists observed that the rodents began to eat less and lose weight.

The researchers also were able to induce the rats to eat more, by blocking nesfatin-1.

?After we injected anti-nesfatin-1 antibody, these rats showed increased appetite and finally showed a progressive increase in body weight,? Masatomo Mori of the medicine and molecular science department at Gunma University Graduate School of Medicine told Reuters in a telephone interview.

Mori said the finding could pave the way for treating obesity, which has become a major health problem in the developing world as well as in economically advanced countries.

There are at least a billion overweight adults across the world, 300 million of them considered obese, according to the World Health Organization.

Obesity has been linked to chronic diseases, such as type 2 diabetes, cardiovascular disease, hypertension and stroke, and some forms of cancer.

Copyright 2006 Reuters Limited. All rights reserved. Republication or redistribution of Reuters content is expressly prohibited without the prior written consent of Reuters.
URL: http://www.msnbc.msn.com/id/15103053/wid/11915773?GT1=8618

Sweet, so I can manipulate my bulking or dieting phases by blocking or stimulating nesfatin-1?

Oh, wait, I have to INJECT IT INTO MY BRAIN??? Dammit…

[quote]Bauer97 wrote:
Sweet, so I can manipulate my bulking or dieting phases by blocking or stimulating nesfatin-1?

Oh, wait, I have to INJECT IT INTO MY BRAIN??? Dammit…

[/quote]

Just give me a holler Id fly over just to inject that. That would be an experience to never forget.

Oh and nice find Doc Interesting read.

How is Montana treating you?

Hopefully as well as it is treating Nate Green. See the ‘Porn Star’ interview if you missed it.

Doc,

Do you have experience treating exertion headaches? I tweaked the C4 (pretty sure) and got wicked headaches during any exertion. Chiropractic was the only thing that helped.

Anyway, an article on it would be a cool read. I just read another post by someone having mystery headaches.

I can tell you exactly how I did it if you are interested.

[quote]Dr. Ryan wrote:
How is Montana treating you?

Hopefully as well as it is treating Nate Green. See the ‘Porn Star’ interview if you missed it.[/quote]

Treating me well Thx Yhea supposed to hook up with old Brokeback (Nate) himself here before to long should be interesting.

Hows life treating you?? Up and rolling again injury free??

[quote]Dr. Ryan wrote:
…new ways to treat obesity in humans…
[/quote]

Anything, ANYTHING AT ALL except excercise and learn what to eat and with some common sense self control.

–Tiribulus->

Ya I’d like to block that too haha.

[quote]Tiribulus wrote:

Anything, ANYTHING AT ALL except excercise and learn what to eat and with some common sense self control.

[/quote]

Yeah, they’ve been trying that for a while. The information is out there, that’s not the problem.

If they can inject something into the brains of the obese to make them not be that way, both my comfort in sitting next to them on an airplane, as well as the Nation’s healthcare costs, will benefit greatly…

The flipside looks prety good too, for people with eating disorders.

Very interesting.

I have my flame retardent suit on as I type this. I try very hard to see things from all points of view, but I just cannot get myself comfortable with all these new and innovative ways to expunge personal responsibility from our society. Gastric bypass, liposuction, now maybe rewiring somebody’s brain. Where will the “disorders” end, if anywhere?

Every single human behavior is now blamed on some sort of psychological or genetic mishap over which nobody has any control. I keep waiting to turn on the news and see the newly discovered “shooting little Amish girls over an old trauma and then offing ones self” disorder being discussed by some panel of self proclaimed experts.

At what point did everything become a sickness of some sort instead of evil or overindulgence in ones appetites and desires?

The message being sent to younger generations if they take the lessons being taught by this seriously is: whatever deviant, depraved or just plain self destructive behavior you may find yourself falling into is not your fault in any even indirect way.

You are a victim of something beyond your control and some new therapy, drug or institution is needed to cure you. I think were way off the path to a stable lasting society with our preoccupation with replacing responsibility with victimhood.

–Tiribulus->