Well, it depends on your definition of "actually". There's an old saying that goes "if you're on TRT, you may as well be on meth" and this does hold some truth, albeit without some of the personal hygiene neglect, save for the occasional missed shower, etc.
Also, by "hold" a job. That's figurative right? Like, "Johnny (or Melissa, it could be any name as the name doesn't hold any substantive meaning here) can hold down a job despite his TRT regimen." I think most are able to "hold" a job, figuratively speaking, and anecdotally, they have excelled at times (myself notwithstanding).
There is also HRT (hormone replacement therapy). This can apply to a woman or a man. A woman will only be given high dosage T (testosterone) if she is interested in sexual reassignment. Otherwise, she may be given small amounts of T to increase her sex drive. Female hormone replacement w/estrogen has more risks from what I understand, but since I'm not a woman (I'm a man), my interest is not very high, thus the apathy.
I'm on testosterone replacement therapy. I'll post my protocol.