one of my doctors prescribed those when I switched to him, and I was on both for over a year.
SIDE NOTE: oral DHEA is known to increase a certain enzyme. That enzyme is what clears drugs, hormones, DHEA, etc. out of your system faster - so the more oral DHEA you take, the faster your body clears it (per dr. mariano I think). DHEA can be beneficial, but only up to a certain amount (like 50mg daily I think) - and it is not for everyone.
for me personally, DHEA seemed to convert to Estriol bypassing Testosterone. while on DHEA, I had to take 1mg Arimidex a day or else I experienced symptoms (but 1mg Arimidex also caused symptoms of its own). Eliminating DHEA allowed me to drop my Arimidex to .25mg EOD.
Oral Pregnenolone can have a valium like effect on some people causing mental fog and other issues. Transdermal Pregnenolone does not show up in blood tests (per Dr. Crisler) and since it does not show up, it is hard to imagine that it is actually doing anything.
JanSz on another forum is doing an experiment and trying out Lipid Matrix Micronized Pregnenolone on the theory that it bypasses the first pass through the liver. He has had some remarkable results with it - taking less Cortisol, less Thyroid meds, etc.)
For me personally, I tested out different combinations and amounts at different times - my results were:
60mg Oral Pregnenolone = possible mental fog and apparant prostate issues (awareness of prostate)
100mg Lipid Matrix Pregnenolone = initial sense of well being, but then zero libido and total loss of physical sensations down below (too much conversion to Progesterone canceling out DHT??)
25mg Lipid Matrix Pregnenolone = immediate awareness of prostate (too much conversion to DHEA to Androstetione to bad 2:16 Estriol ratio??)
I will be getting a blood test this week so I will be able to see what my levels are now off of Pregnenolone and DHEA vs the time I was on 50mg DHEA and 60mg oral Pregnenolone + a whole host of conversion ratios -
My wife (who has multiple thyroid, estrogen, progesterone issues. her last pregnenolone test showed she was at 7 (yes, only 7 - with a range of 20-150). I am trying to convince her to give Pregnenolone a try, but she is resistant. She will be getting a new workup in a week or two, so if those come in drastically low again, then I am going to push the issue some more.