T Nation

Anxiety and Side Effects. Split Dose?

I am 38 and I have been on TRT for two years.
The past year I was switched from Cypianate to Enanthate. I never really had issues with the Cypianate but the clinic decided my Test numbers were not high enough and thought I would respond better to the Enanthe. I also was give HCG 3 shots per week. My dose went from 150 weekly to 225 split over the week. I noticed the last 6 months I have not felt like myself have became extremely jealous and moods swings all over the place 1 week ago the clinic decided to not split my dose any longer. I have no reason as to why. I took the shot which put me into a tail spin. I could not calm down not matter what. Extreme anxiety and depression!!! A good family friend who is a nurse practitioner at a T clinic immediately suspected Estrogen was out of control and way to much T al at once. She gave me progesterone which almost immediately helped relieve the anxiety. Today i went to my doctor to have a complete hormone blood test completed along with thyroid ect.

I understand with out the labs it will be hard to give solid advice but
My questions are. I am not afraid to take any remaining doses. The anxiety has some what subsided but now I have muscles twitching all over my entire body. Any ideas on what could be causing this. Any ideas on where to start from here. Should I try going to a lower dose split across the week? Should I give
More time to get this out of my system and start over? I apologize for the lack of labs I hopefully will have some answers tomorrow

I noticed your problem right off the bat, no arimidex to help control estrogen conversion. Clinics are typically filled with stupid people who go against the norm. The only difference between cypionate to enanthate are their half lives, cypionate has a slight advantage in half life. HCG is known to be a beast for estrogen for some guys. When guys have high estrogen they become angry bitches.

What a bunch of foolish incompetent people, these doctors at these clinics often have no idea what their doing. They learn from messing guys up and using you as guinea pigs, just like a dental groups where they have a bunch of interns. Stop the HCG until you get prescribe an AI, no more than 1mg per 100mg of testosterone or preferable less.

Your test dosage is insane and is no wonder why you’re having problems, inject 50mg twice weekly. These clinics prescribe toooooo much testosterone because it’s the only way to turn a profit. You need to educate yourself because it’s the only way to spot trouble, this is the right place to start.

I seriously doubt you have enough labs to design a successful protocol, suggest you find a competent non-insurance doctor.

You need to take charge of your own health because no one else is going to do it for you.

Thank you so much for your response. I feel like such a fool for not educating myself!!! Again thanks for taking the time to respond. More than I have learned in two years of going to the clinic I was going to

I am taking your advice and dropping my dose. My question is should I step down slowly from 225 to 100 or can i adjust to the new dose? I am staying away from the HCG. Unfortunately they will not give me an Al but I was told if I take high dose zinc this can help me control the E2. The problem is my last lab was in January and is very vague. Testosterone was 560 no free was given. My E2 was <10

I think I felt my best with my T was in the 450 to 500 range and my E2 was consistent around 24
I know that info probably doesn’t help much.

I have a new actual T doctor starting in April I just need to make it work until then

I continue to have issues with high blood cells and have to give blood

If your having problems on that dose with H/H, and e2. then going to 100 mg should fix all that.

You don’t have to titrate down. Zinc does work to some extent, but you might not even need an AI…

Stop Ai if you are dropping dose. 100%

You need to self-inject T twice a week.
Take anastrozole at time of T injections at rate of 1mg anastrozole per 100mg T. Example inject 50mg T and tale 0.5mg anastrozole.

250iu hCG EOD or 3x per week.

T injected subq is smoother T levels and then works better with anastrozole.

A zinc deficiency is a problem. Beyond that zinc is rather inadequate.

We see some anxiety and panic attacks associated with low iodine and low thyroid function. Yes, elevated E2 can make such worse again.


Please read the stickies found here: About the T Replacement Category

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  • things that damage your hormones
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Evaluate your overall thyroid function by checking oral body temperatures as per the thyroid basics sticky. Thyroid hormone fT3 is what gets the job done and it regulates mitochondrial activity, the source of ATP which is the universal currency of cellular energy. This is part of the body’s temperature control loop. This can get messed up if you are iodine deficient. In many countries, you need to be using iodized salt. Other countries add iodine to dairy or bread.

KSman is simply a regular member on this site. Nothing more other than highly active.

I can be a bit abrupt in my replies and recommendations. I have a lot of ground to cover as this forum has become much more active in the last two years. I can’t follow threads that go deep over time. You need to respond to all of my points and requests as soon as possible before you fall off of my radar. The worse problems are guys who ignore issues re thyroid, body temperatures, history of iodized salt. Please do not piss people off saying that lab results are normal, we need lab number and ranges.

**The value that you get out of this process and forum depends on your effort and performance. The bulk of your learning is reading/studying the suggested stickies.**strong text

When injecting once a week, T and E levels are changing all of the time and lab results are mostly determined by lab timing.

I went to new Dr yesterday, she was openly honest about not knowing enough about TRT but encouraged me to find a new clinic. She ran a full thyroid panel and metabolic panel urinalysis and several other test. I am waiting to see what the results are. Prior to me posting I read a lot about the thyroid so what your saying makes sense. We have a huge family history with Thyroid issues. I am taking all you are saying to heart and will keep up on this. I just want to feel better. Thanks for all your help

I have some labs in ans still waiting on others unfortunately not sure they are going to tell you enough.

TSH 2.334 mcU/ml
Tesosterone 422 ng/dl
Cholesterol 287 mg/dl
Triglycerides 300 mg/dl
HDL 33 mg/dl
LDL( Calculated) 194 mg/dl
Glucose 99 mg/dl
WBC 11.3 k/cumm
RBC 5.74 million/cumm
Hemoglobin 17.9 GM/dl

So far these are the only test I have back. I am going to start taking body temps in the morning.