Anybody use Damiana and have blood work done (hormonal profile)?
Apparently some of the constituents of the herb are have anti-aromatase activity (which is good). The fact is, with the straight herb, there are other constituents that have pro-estrogenic activity. Thus it seems (to me), purely from a hypothesis point of view, that the substance could potentially might act as a SERM if the overall activation is lower and binding affinity higher than estradiol (competitive inhibition). For example, you have a SERM like tamoxifen which also has mixed effect as well (agonistic in some tissues while antagonist in others).
The study: (I’m sure there are others as well)
Anti-aromatase activity of the constituents from damiana (Turnera diffusa).
Zhao J, Dasmahapatra AK, Khan SI, Khan IA.
Department of Pharmacognosy, School of Pharmacy, University of Mississippi, University, MS 38677, United States.
ETHNOPHARMACOLOGICAL RELEVANCE: Damiana (Turnera diffusa Willd. Ex Schult) has traditionally been used as an herbal aphrodisiac. AIM OF THE STUDY: The study was aimed to investigate the anti-aromatse activity and the estrogenic activity of the constituents isolated from Turnera diffusa. MATERIALS AND METHODS: The methanolic extract and 24 compounds isolated from the leaves of Turnera diffusa were evaluated for aromatase activity by using a tritiated-water release assay and for estrogenic activity by using yeast estrogen screen (YES) assay. RESULTS: The methanolic extract demonstrated a dose-dependent inhibitory activity of the aromatase enzyme with the IC(50) value of 63.1 microg/ml. Among the 24 tested compounds, pinocembrin and acacetin showed the most potent inhibition with IC(50) values of 10.8 and 18.7 microM, respectively. Estrogenic activity was also observed in the extract and three compounds including apigenin 7-glucoside, Z-echinacin and pinocembrin with EC(50) values of 10, 20 and 67 microuM, respectively. CONCLUSIONS: The extract of Turnera diffusa and two isolated compounds pinocembrin and acacetin could significantly suppress aromatase activity. Moreover, apigenin 7-glucoside, Z-echinacin and pinocembrin showed estrogenic activity. [/quote]
Anybody got any additional info, or know if there is a product that is credible?
Also FOR BILL ROBERTS: Is it cost effective to isolate the pure extracts (from a manufacturing perspective)?