I found this article while doing some research on various hormones involved in diabetes:
Ghrelin is a complimentary hormone to leptin, BTW.
“Testosterone Replacement Therapy Restores Normal Ghrelin in Hypogonadal Men”
Some interesting extracts from the abstract;
"Total and free T and plasma ghrelin levels were significantly lower in the hypogonadal men than in the control groups. Hypogonadal men also had a significantly higher insulin resistance state. "
That seems to imply that hypogonadal men are more prone to Syndrome X. Also, since ghrelin stimulates stomach acid production, hypogonadal men will probably be prone to digestive disorders.
“After the 6-month replacement T therapy, ghrelin levels of hypogonadal patients increased and did not differ significantly in comparison with both control groups. The positive correlation between ghrelin and androgens still persisted after T replacement therapy, after adjusting for confounding variables.”
“These data further indicate that sex hormones modulate circulating ghrelin concentrations in humans. This may be consistent with the concept that ghrelin may exert a relevant role in the endocrine network connecting the control of the reproductive system with the regulation of energy balance.”
Another good reason to be on TRT.