T Nation

androgen blood levels

I have searched the site to death for a definitive answer on actual blood level measurements for testosterone and androstenediol increases with the use of Androsol. Bill Roberts mentioned an increase of 300ng/dl for testosterone with the max Androsol application. Can we expect this level to remain elevated concurrent with the increased androstenediol level (12-24hrs)? Why isn’t more being converted to T? On second thought, I think I did see a graph that showed huge increases in androstenediol levels following androsol application, but it lacked an explicit commentary. Perhaps an explicit commentary? Lil’ help? Anybody out there?

What seems to be happening is that the enzymatic conversion of Adiol to T is saturated whereby you will not see elevations in T much greater than 300-500 ng/dl, depending on the individual. Specifically with regard to the Androsol study, Adiol was elevated approximately 5 fold from 3-10 hours and returned to baseline by 24. T was elevated for the entire period and remained slightly elevated at 24 hours. Whether this is conveted T that remains elevated longer than Adiol because Adiol is cleared faster or simply an artifact is difficult to say. I would rather not go into greater detail until the study is published.

Total 4-androstenediol, ng/dL

(h = hours)

Placebo: 0h, 958. 3h, 872. 10h, 745. 24h, 883.

Androsol:0h, 883. 3h, 3120. 10h, 3610. 24h, 998.

Total testosterone, ng/dL:

Placebo: 0h, 764. 1h, 589. 2h, 566. 3h, 577. 10h, 457. 24h, 574. 48h, 564. 72h, 567.

Androsol:0h, 674. 1h, 643. 2h, 623. 3h, 726. 10h, 822. 24h, 762. 48h, 597. 72h, 678.

Free T, pg/mL (this is the only T reading that
really matters)

Placebo: 0h, 18.7. 1h, 14.5. 2h, 14.6. 3h, 14.5. 10h, 15.1. 24h, 17.6. 48h, 16.9. 72h, 15.8.

Androsol:0h, 18.7. 1h, 17.9. 2h,18.2. 3h, 22.4. 10h, 21.6. 24h, 23.3. 48h, 18.5. 72h, 19.7.

Unless you want to do math, you’d be better
off with the graphs rather than with the tables.

To summarize the data, it’s best to consider
area under the curve, or for simplicity, the mean difference from baseline over time.

For total testosterone, 0 to 24 hours, mean difference, ng/dL:

Placebo: -326 (T levels ordinarily decrease during the day from a morning reading so this
is not unusual.)

Androsol: +96. Improvement relative to placebo, an average of 421 ng/dL higher relative to its baseline than placebo was relative to its baseline. This is 62%.

Free T, pg/mL, mean difference relative to baseline:

Placebo: -2.9

Androsol: +3.2. Improvement relative to placebo, an average of 6.1 pg/mL higher than baseline. This is 33%.

Total 4-AD, ng/mL, difference relative to baseline over 10 hours (unlike the T measurements, there is a large difference in values between 10 and 24 hours with no intervening measurements so I do not want to include that area. A previous salivary test did show however that 16 hours was about midway between values for 10 and 24, but still I’d rather use only this data.)

Placebo: -118

Androsol: +1747, which is an improvement of 1865 relative to placebo. So Androsol use increased 4-AD levels – which by the way are higher in the body than T levels even when 4-AD is not being used! – by more than three times.

Our salivary testing indicated that free 4-AD plus free T increased by about 20 times. This study unfortunately did not include free 4-AD. It was an outside study and they did not consult with me on it (understandably so: wanting to be independent.) Free 4-AD would have been the most valuable measurement in my opinion, but as you can see, they were focusing mostly on testosterone because, as most people do, they felt that testosterone was the androgen of main interest.