T Nation

Analysis of Studies and Steroid Risks


#1

hello guys, this is my first post in this great forum.

I’m always in new discussions on the topic, how dangerous is anabolic steroids? im always beeing looked at like an idiot becus i dont understand the basic, “if you take steroids you either become a girl or die” so im looking at various studies published on pubmed to see if anyone serious have made and good study. so i ended up with this study, is there anyone here who can help me analyze this? and give me some good points to bring to other discussons?

http://www.sciencedirect.com/science/article/pii/S016752731200277X

thaks
Erik


#2

That study did not look at what AAS were been used. Some are harmful and some may be used in amounts that are harmful. Some oral AAS are well known for toxicity. The study is not very useful other than to say that some AAS users create health problems.

Testosterone is a human hormone and does not have many negative aspects when used safely. That implies doing lab work to see how one’s body responds. Unfortunately, that is rather rare as young men who do AAS simply think that nothing will happen to them. Some people simply behave in risky ways.

So what are you expecting to accomplish with your quest?


#3

I dunno if you’ve seen this KSman but you might find it interesting:

Long-term Testosterone May Decrease Cardiovascular Risk
Kate Johnson
May 10, 2016

SAN DIEGO — Long-term testosterone replacement therapy is associated with a decreased — not increased — risk for cardiovascular disease in men, according to a large population-based cohort study.

This finding “answers the controversy” fueled by recent warnings from the US Food and Drug Administration (FDA) suggesting that the opposite is true, said senior investigator Robert Nam, MD, from the Sunnybrook Health Sciences Centre in Toronto.

The study was published online May 7 in Lancet Diabetes & Endocrinology to coincide with its presentation here at the American Urological Association 2016 Annual Meeting.

On the basis of this study, “we can conclude that long-term testosterone is safe,” Dr Nam told Medscape Medical News.

“We need to do further study, but with our large sample size and long follow-up, these data provide some powerful findings,” he explained. “Physicians still need to individualize their recommendations to patients, but it certainly helps to address some of the controversy around testosterone.”

The FDA recently required testosterone products to carry a warning about possible cardiovascular risk, as reported by Medscape Medical News. But that ruling was made on the basis of studies with a short duration of treatment, short follow-up, and no dose–response analysis, said Dr Nam.

“We weren’t convinced that long-term testosterone had a detrimental effect because all the science says otherwise. That’s why we wanted to look at it in a larger population with a longer duration of use,” he explained.

The study involved 10,311 men 66 years and older newly treated with testosterone replacement therapy and 28,029 untreated control subjects, all gathered from Canadian databases.

Control subjects were matched for age, comorbidity, diabetes, region of residence, and index year.

At a median follow-up of 5 years, overall mortality was lower in patients treated with testosterone replacement therapy than in control subjects (hazard ratio, 0.88).

Duration of Treatment

When the duration of exposure was analyzed, mortality and heart-related morbidity were higher in patients who received short-term therapy (median, 2 months) than in those who received medium-term (median, 9 months) or long-term (median, 35 months) therapy. There was a “protective effect against both mortality and rates of heart-related events” with longer duration of treatment, Dr Nam reported.

Specifically, with short-term exposure, mortality increased by 11% and cardiovascular risk increased by 26%. However, with medium-term exposure, mortality decreased by 10%, and with long-term exposure, mortality decreased by 33% and cardiovascular events decreased by 16%.

There was no increase in prostate cancer risk with short-term exposure, and the risk decreased with increasing exposure; with long-term exposure, prostate cancer decreased by 40%.

Importantly, when the investigators looked at testosterone exposure over time, they controlled for immortal time bias, which can falsely attribute short-term risk to a treatment when deaths are actually due to the treatment having not taken effect, explained lead investigator Christopher Wallis, MD, also from Sunnybrook.


#4

We have seen several reports to this effect.

Remember the lawyers ads were on TV? A VA researcher looked at VA guys on TRT and compared to those not on TRT and heart attacks and strokes were strongly reduced. When that news came out, the lawyers stopped waiting their money.


#5

thanks for the reply :slight_smile: so there is somthing flawed becus they actully dont know how mutch or have controll over other substans use/abuse so they cant draw a good conclusion?

what im trying to accomplish is just info and learning. im a young student trying to get the facts and not just bullshit from mainstreame media.


#6

The truth gets washed around with the tides of medical publications, FDA nonsense and mainstream press and the lawyers are always seeking things washed up that they can eat.

TRT is safe. The earlier it is done, the less damage that occurs from living with low-T over time. Starting TRT on an 80YO guy who has suffered from years of low T and catabolic wasting is wrong in several ways.

Maybe someday society and doctors will wake up to see that TRT improves life span and quality of life [QOL]. And the net effect would be a lowering the societal cost of health care. TRT could be managed cheaply as main stream instead of boutique medicine that most cannot afford.

Another aspect that I run into is that most people do not care about their general health and only want to go to a doctor when there is pain, disease or inability. So while we see the way things are at sites like this; most men don’t know or care. Talking to them in real life is like talking to a wall. Perhaps that could change if doctors were starting the conversations. But then, most men would be ignorant passive sheep.


#7

@KSman, what are your thoughts on the potential fertility issues that can supposedly arise from long-term testosterone administration?


#8

if you are wondering on the subject, this is a great video on that problem


#9

thanks! I’ll check that out


#10

The videos with Dr Rand are great - i highly recommend watching them