Thank you InTheZone and Contrl, exactly the kind of info I was looking for!
Contrl, i seem to remeber having read that anadrol won’t aromatise to any degree, so an aromatase inhibitor such as arimidex would be ineffective in preventing gyno. Nolvadex would be the only solution according as this blocks the estrogen-receptors. Anyway can’t remember where I read it, so maybe I’m getting things mixed up.
Nolvadex is a SERM, which stands for Selective Estrogen Receptor Modulator. It, like Arimidex, acts as an agonist/antagonist in that it inhibits estrogen from binding to receptors. The difference between these two compounds is that one selectively binds to specific tissue (namely the glandular tissue in the case of Nolvadex), while the other (Arimidex) has a broader physiological effect. By no means does Nolvadex thoroughly block estrogen receptors through and through.
The purpose of adding an AI to this specific Anadrol/Winstrol cycle would be to minimize the inherent bloat that comes from Anadrol (Oxymetholone). There are also various reasons why not to use Nolvadex during cycle, but I won’t get into those.
Ok, I found this at bodybuilding.com (Big cats anadrol profile):
“With the estrogen increase of course comes the increased risk of more side-effects such as gynocomastia (growth of breast tissue in men). Therefore its always advised that a cycle of oxymetholone is accompanied by the use of an anti-estrogen such as Nolvadex. Nolvadex, keeping in mind that aromatase enzyme is not involved, would be the wiser choice as it blocks the receptor for estrogen rather than the aromatase enzyme. Its wise to note as well that the gains from oxymetholone are largely mediated by estrogen, so reducing estrogen may reduce results as well.”
and from the arimidex profile:
“As mentioned, arimidex is an ancillary that is supposed to be stacked with aromatizing steroids in order to stop all formation of estrogen. Its seemingly very potent, so doses of 0.5 to 1 mg are enough. Some claim that 0.25 mg is enough, but for anyone doing any sort of serious cycle, I would not advise less than 0.5. These steroids are, without exception testosterone, nandrolone, norethandrolone, boldenone and methandrostenolone. And all of their derivatives as well. The drug oxymetholone (anadrol) has estrogenic effects as well, but they seem to be the result of oxymetholone’s acidic A-ring activating the estrogen receptor by itself, rather than by conversion to estrogen. So Nolvadex would be more advisable in that case. To understand the whole story, I refer you to my profile on Anadrol.”
So, according to him arimidex would work great with drugs like dbol or testosterone, where test aromatises into estrogen, but not so well with anadrol where there’s little if any conversion to estrogen. Here, the blocking of the estrogen receptor itself should be more efficient?
Steroid profiles such as big cats have led me to believe that arimidex is an aromatase inhibitor, and that the SERMs (clomid, nolvadex)are not, and that their actions are quite different. Still I see what you say about arimidex also reduces waterbloat, so maybe it would be good to have it on hand.
Clearly, this “Big cat” fellow is an idiot.