I’m considering the merits of a Anadrol and Var 2 week cycle with a low dose Dbol for estro. I’ve read Bill’s Anadrol profile over at Meso with a key concern being the potential for gyno (with or without aromatizing compounds) due to progesterone or prolactin?
I found this post by Anthony Roberts which suggests their is no gyno without estrogen, but this was posted a few years ago and I’m interested to see if a consensus has been reached on the subject.
"A cursory knowledge of anadrol would tell these reliable peeps that since anadrol is derived from DHT (as is winstrol), it would likely have the same progesterone inhibiting ability as the winstrol would. In numerous studies, we see anadrol inhibiting progeserone biosynthesis in women.
Here’s one, if you want to look it up:
Am J Obstet Gynecol. 1975 Jan 1;121(1):121-6.
As for the idea that letrozole won’t help gyno “caused” by progesterone(or that AI’s won’t help that kind), that’s bullshit. The basic biology of breast cancer and breast tumors (which is what gyno is…a benign breast tumor) indicates that estrogen contributes to its development, and that it is essentially estrogen dependant. Nearly all existing mammary tumor models in most species confirm this. Human models, animal studies, in vitro, in vkivo…you name it…it’s estrogen, not progesterone. Estrogen grows the gyno, not progesterone. Concerning progesterone, actually, In some studies it actually has an inhibiting effect on breast cancer growth and tumor development.
Harris JR, Lippman ME, Morrow M, Osborne CK, editors. Diseases of the breast. 2nd ed. Philadelphia: Lippincott, Williams & Wilkins; 2000. p. 335-54.
Ergo, there is no real “progesterone” gyno, and AIs will work for gyno of any kind.
Letrozole actually reduces progesterone levels in the body, if you are interested. Sooo…even if there were progesterone gyno (ha ha), letro would get rid of it.
Thanks in advance