T Nation

AI Dosage Question


#1

Okay, so I have started 1 mg of anastrozole per week, taken EOD. They are very small pills, so it is fairly difficult to quarter them. I have now taken them for three weeks. My Estradiol levels have dropped from 47 to 37, with the normal range being 10-44. I do feel better now, but still not great.

My question is, will my levels continue to drop, or do I need to adjust the dose? If I need to adjust dosage, what should I go to? Note that I am self medicating, as three different doctors have turned me down for an AI and HCG, even though I am prescribed 1 mg Test Cyp per week for TRT. Thanks for any help guys!


#2

I would continue at the same dose. A drop of 10 points in only 3 weeks means your body is clearing E2 normally. Anastrozole won't make it clear any faster but will prevent excessive aromatization. I'm assuming you mean 100mg cyp/week.

I've decided most Dr.s are still d*icks and have yet to let go of the paternalistic mentality. If you're going to your family Dr. or walk-in clinic those drugs are out their clinical expertise and you should look to a specialist or, I hate to say it, alternative medicine. There is a finding a Dr. sticky posted that might be helpful.


#3

Yep, sorry, 100 mg of Test Cyp per week. I've seen two urologists and my family doctor. Next up is an Endo, but I am calling ahead of time to make sure I don't waste my time. If they don't answer my questions sufficiently during that call, I'm not going to drive 3+ hours to see them. Thanks for the advice on the AI.


#4

I'm just following along would like to see where you go with the AI dosing as I'm on the same dose/frequency and feel like mine is still >22; ED symptoms


#5

Use the finding a doctor sticky for a doc that will prescribe HCG. Most doctors open to that will most likely be more open to idea of an AI as well.


#6

Good question. I was wondering about the same thing. I was put on Adex after my labs showed my E2 over 50. So I was wondering if the Adex will clear the already aromatized E2 and prevent further aromatization or will it just stop the aromatization from this point forward ? If the later is true, then would Femara clear the existing E2 if taken in very small doses for a short period of time?

Current protocall:
100 mg test cyp. Per week in divided doses.
250IU HCG EOD
.25 Arimidex EOD


#7

The effect of anastrozole on T--E2 is basically instantaneous. E2 clearance take time, but by 3 weeks a lot should have happened.

There is a question of liver function, AST/AST and drugs [Rx and OTC] that might interfere with estrogen processing. High BMI can be an issue too.

TT, FT and E2 will all be very spiky with weekly injections, injecting T twice per week [divided doses] is important, or perhaps EOD.

If we accept the current numbers without question, we would calculate a new anastrozole dose to read E2=22 of 1mg/week * 37/22 = 17 mg/week, which can be 71/4ths of a mg. You can do that at 1/4th per day but 1/2 EOD would be easier. You will feel better. But I am very suspect that the info presented is incomplete.

Dr=[Rock Creek Wellness Center] $$
tell him that I sent you if you go in


#8

Thanks KSman. I've considered Dr. Mark after seeing you recommend him in another thread. Also, what info do you feel is incomplete. I can try to add if necessary.