The effect of anastrozole on T--E2 is basically instantaneous. E2 clearance take time, but by 3 weeks a lot should have happened.
There is a question of liver function, AST/AST and drugs [Rx and OTC] that might interfere with estrogen processing. High BMI can be an issue too.
TT, FT and E2 will all be very spiky with weekly injections, injecting T twice per week [divided doses] is important, or perhaps EOD.
If we accept the current numbers without question, we would calculate a new anastrozole dose to read E2=22 of 1mg/week * 37/22 = 17 mg/week, which can be 71/4ths of a mg. You can do that at 1/4th per day but 1/2 EOD would be easier. You will feel better. But I am very suspect that the info presented is incomplete.
Dr=[Rock Creek Wellness Center] $$
tell him that I sent you if you go in