First off, this might be go a little off topic. But this message means a lot to me, exactly like what i looked for and to discuss. And i really need to hear your thoughts. I want to start by asking the biggest concern of mine about this disease:
Well, i really don’t have a proper knowledge about the genes and how things work there. But yes i heard about that epignetic damage thing. Is there a chance of taking Accutane only for 3 days at 16, could have impaired my height and bodily development as a man? (This is impossible for normal people but im asking this, regarding that i developed PAS from that 3 doses.)
We know Androgens play a big role on that aspects. I have read papers that state that the jaw growth continues up to age 25 and the most significant part is between 18-20. I basically had a shitty sexuality at those ages. Numb orgasms, watery semen etc.
Was it the low T levels in general (im not sure how few doses permanently lower my baseline thyroids.) or spesific cell or receptor damage? I have no idea and that’s the problem.
I don’t really feel comfortable in my own body, this is so traumatic. Only thing i think is: What would i look like if i never took the drug? Would i be taller more masculine looking? Etc. I feel like my genetical programming is halted. (Just a feeling, im at the same height as my dad.)
And the only way out from this loop is to think about the ‘‘tissue spesific damage’’ theory. As you also stated, if i understand this correctly, is there a chance that, let’s say, Accutane only damaged my Prostate tissue (Receptors, cells?) and the rest of my body was untouched or undamaged by this drug? Maybe it didn’t lower my LH or T permanently and only damaged spesific AR tissues?
My uncle was also used this drug for long periods and he is the tallest in family… i really don’t understand this. On the other hand i get PAS with only 3 doses.
I keep holding to this dream. That the issue might be tissue and cell spesific. (Some PFS sufferers can build muscle but have still ED etc.) My problems very similar to Prostatits sufferers. I wish it is somehow more possible and true. If not, do you think if i recover soon, could my body re-open its true genetical potential and programming and hit a semi second puberty at 22? I have no idea if Accutane damaged my LH and GH levels permanently, many people said it can’t do this. But they didn’t consider the negative AR feedback to HPTA which is explained in the link i’d share.
For the other things, im thinking to heal myself with GYM and low dose clomid support. Beginning next week. I don’t know if there is anything else to do at this moment. I don’t have any mental issues like SSRI’ sufferers.
Again and again, i really thank you for your time, you have no idea how much you are helping me right now. This really means a lot!! When you have time sir, im here.
Here is an article which may help you to understand this disease better, if you care to check:
http://www.protocol-online.org/forums/uploads/monthly_08_2010/msg-19273-027408800%201282061244.ipb?fbclid=IwAR2Po4B8JUqEaQu5JFbqgi0Oj9Gw1LqIsvFU2tC-h4p1N3kVBPZBax6omWA Here there are some sentences about isoforms, spesific isoforms, is this corraltes with the tissue spesific damage thing?