I have searched this forum and others, read a few clinical studies, and cant seem to find a good answer on exactly how anastrozole works.
Assume someone has nailed down their anastrozole dosing to get their estradiol into the “sweet spot” around 22 pg/mL with their current testosterone regime. Now that individual wants to increase their testosterone dosage to raise total T. Will that individual need to increase their anastrozole dosage to stay in the ideal range? If so, will the dosage increase of anastrozole correlate with the testosterone increase, ie. a 20% increase in testosterone cypionate should require a 20% increase in anastrozole?
I ask because on my initial post KSman recommended 1 mg per every 100 mg Test Cyp. Another member, Nashtide, explained that anastrozole attaches to aromatase and as you have a fixed amount of aromatase in your body, increased testosterone shouldn’t effect the impact anastrozole has on estradiol. I cannot find anything correlating an increase in testosterone with an increase in aromatase production, so Nashtides assessment makes sense.
So to summarize my questions, is anastrozole dosing connected to testosterone dosing or is it dependent on ones fixed aromatase levels? Does an increase in total testosterone allow the unbound aromatase to create more estrogen then it would at a lower testosterone level (more gas pumped into the same sized burner)? If increased testosterone dosages does require additional anastrozole, is there a general rule of thumb for titrating the anastrozole to accommodate the increased testosterone?