The DHEA is strange. Eugene Shippen claims that high levels of DHEA can start to block T at T receptors as does E2. Pregnenolone is made in the testes and is lost with HPTA shutdown. hCG recovers that production. 250iu hCG would make less. Pregnenolone is the feedstock for DHEA production in the adrenal glands.
It might be worth been mindful that the adrenals could be over active if other adrenal related concerns arise - ?panic attacks? Anybody else able to speak to this?
When you get things steadied out, then you will be able to feel the effects of changes you make when not getting shotgunned. You can then read your body.
The dopamine hit from injecting seems to wear off anyways. Things like that do not seem to be sustainable. Some get in trouble chasing that lost glory. Some of the nice things about [starting] TRT seem to be once in a life time events.
Arimidex does not block out aromatase, it interferes with T reacting with the aromatase enzyme. If there is more T bouncing around, you need more arimidex to Be able to statistically interfere with the higher potential T-aromatase hits. T and arimidex compete for the attention of the enzyme.
Arimidex does not react there, but T does. There is a drug that does bind to aromatase and disables it. Sounds wonderful, but the dosing and cost is high and the results not any better. If that drug was really good, it would be a mainline breast cancer drugs… which it is not.
Depression: If you have trouble sleeping, try 50mg trazodone at night, and expect to see a need to get to 100mg in short term. it is a $4.00 per month generic. It is dopergenic and can fix some depressions. No side effects if dosed properly. Improves libido in many cases. After that, one can add Wellbutrin.
Dostinex [.5mg/week] also improves dopamine in a better way as it can avoid the systemic [over] stimulant effect of Wellbutrin. But docs who will script that may be one in a million. All three are libido friendly.
Many guys who don’t seem to shine with TRT who are not typical profoundly sad depressed are really showing the effects of low dopamine. The dopergenic drugs seem to be neglected in favour of SSRIs that for most simply make quality of life worse.
Other complicating factors are diet, lack of trace minerals and vitamins, lack of health fats and often thyroid problems. I keep selling vitamin D. I have one report where the effects were very very positive. The world is slowly understanding the role of vitamin D. Does not have to be oil based as many do well on dry types and much research has been done with dry types.
However, the oil based vitamin D may have better bio-availability for some, perhaps profoundly better. 2000iu tiny oil based caps are now available.[/quote]
Awesome post, thank YOU