This is essentially a re-post from a different forum, but I think this may be a better place for the topic.
I’m currently 39 years old. I’ve always been into bodybuilding, but that kinda took a nose-dive almost 10 years ago due to the use of Dutasteride for hairloss (from 2005 to 2010). Long story short I developed Post Finasteride Syndrome (PFS) and haven’t been the same since. Drastic negative changes in body comp (muscle atrophy/subq fat), energy, libido are the big 3 symptoms, although there are plenty of other smaller but significant symptoms as well. I eventually had to go on TRT long term a couple of years ago, but I am still suffering PFS symptoms and am having difficulty dialing everything in.
My current Protocol is:
Test E: 40mg x 2x/wk (SubQ)
HCG: 400iu’s x 2x/wk (SubQ)
Multivitamin (Garden of Life - Men’s)
Blood Sugar Support (for the additional Zinc/Magnesium)
Vitamin D3 4000iu’s
Fish Oil 1000mg
Nascent Iodine 4mg, with Selenium 200mg (past 2 months due to low body temps - suspected Wilson’s Syndrome)
My last TRT bloodwork was as follows:
TT: 884 ng/dL (R=240-950)
FT: 23.9 ng/dL (R=4.65-18.1)
E2: 35 pg/mL (R=7-43)*
SHBG: 30 nmol/L (R=13-90)*
Everything else has been in good order (but feel free to inquire further). I’m having more BW results coming in tomorrow, which will include some expanded thyroid testing. The only change I’ve made since last BW is dropping T dose from 90mg/wk to 80/mg/wk (trying to get FT & E2 in range/optimal).
I’ve experimented with higher doses of Test, which seem to make me feel better initially/intermittently but also causes me to have some really bad days. The lower current dose has been a lot more even-keeled feeling. But regardless of the dose, I seem to have only about 3-4 hrs of decent energy in the beginning of the day (unless I consume copious amts of caffeine). I’ve also tried AI’s when my Test/E2 was a little higher (around top of range), but am overly sensitive to them - for example, 1/4 tab 2x/wk of Anastrozole or Exemestane is still too much (although the Exemestane is a little gentler and takes longer to crash me).
Based on everything I’ve read about my symptoms and PFS in general, I still have Estrogen dominance. I’ve heard this can cause an entire cascade of issues (including thyroid, which is why I just asked for more testing).
This led me to explore adding Proviron to my current TRT protocol, which I will be able to start later this week. It seems that PFS guys like me have down-regulated/de-sensitized androgen receptors that lead to E dominance. This is where I want the Proviron to kick in and regulate.
Planning 25mg/day. Any thoughts or suggestions would be greatly appreciated…