Adding NPP to TRT

Ah I see. I think it would have served you well to keep the test as is and blast some masteron or other DHT based AAS but im glad it worked. @studhammer

SB

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Agreed 100%, hence my advice to you to keep your Mast in cycle. Damn, how old do I have to be to stop learning the hard learned lessons??

Haha I dont think we will ever stop learning things the hard way, we keep pushing until thats the only way to learn. Thats me anyway. @studhammer

SB

@Singhbuilder,
Hey brother, on another note. My daughter will be there the week of the 18th. Turns out she is presenting at Oxford, not Cambridge (WTH do I know? Iā€™m a Texas redneck). Anyway, I forwarded her your and the otherā€™s recommendations. She is excited to do as much as she can. Already planning on seeing a play and getting some good Indian food. Hopefully lots of fish and chips and beer too. LOL

Thank you so much for your help. If you ever get down to our ā€œcountry within a countryā€ please let me know. There are a ton of us from Texas, surely we could figure out something.

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Ah glad to hear that brother. She will love it. But presenting at Oxford, man thats something to be proud of! She must be insanely smart! Good on you, you must be proud.

Im actually in the states during that week! I hear of the hospitality of Texans, the food and the weather. Sounds like my kinda place, if I ever get the chance to get down there (I know I will for certain) I will be sure to give you a headsup! @studhammer

Side note, I frontloaded NPP yesterday at 100mg and I will be doing 30mg Mon/Weds/Fri, I dont know if its placebo but man my joints already feel good and I look full as hell! It could be a combo of the higher calorie intake and rebound from the prep diet but I certainly feel good.

SB

This is my guess. Ever hear of 'compensatory gain"?

Compensatory gain is defined as a faster than normal rate of gain after a period of feed restriction. It typically occurs in cattle that have been previously restricted or maintained on a low plane of nutrition.

Disregard the Cattle reference. Still applies to most of us.

Donā€™t worry, the NPP will kick in.

Very proud Daddy. She is a PhD candidate and this is from her dissertation.

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Deca dick tends to be caused by serotonin and dopamine depletion, nand tends to cause this fairly rapidly. Nand is also v harsh on endothelial functioning, likely a good deal more cardiotoxic than test

What would be the preventive measures against this?
@unreal24278

SB

Against neuro effects?

Cocaineā€¦ Just kidding, just methamphetamine (not serious) however there are certain pharmaceuticals, both legal and illicit that increase dopamine output such as nicotine, dextroamphetamine, cabergoline etc (dopamine agonist). Of course the first two are fucking terrible ideas (nicotine being highly habit forming when used in any preparation be it a cigarette, patch, gum, whatever, short in duration of action etc). Furthermore, massive spikes in dopamine induced by pharmaceuticals tend to downregulate the brains response to dopamine secretion, and thus dysregulation within reward pathways (mesolimbic system) occurs, thus the user needs more and more to feel the same (this is talking about recreational drug abuse), although this is merely a fraction of the equation that leads to dependence. Interestingly, AAS that increase dopamine output like test, mast and Dbol can have a similar effect regarding dopamine dysregulation over time

Best choice (well what Iā€™d do), and Iā€™m no expert, is to supplement with 5-htp and l-tyrosine, providing you arenā€™t on SSRIā€™s/SNRIā€™s or drugs with such properties like tramadol (this relates to 5-htp not the tyrosine).

As to cardiac effects, regular exercise, abstain from excess alcohol and drug intake (well, drugs that are known to be cardiotoxic anyway), good diet, Curcumin, fish-oil, blablabla.

Ace inhibitors and ARBā€™s are used to treat heart failure and LVH so would potentially be of help, but they themselves can cause issues and itā€™s generally not wise to continually add prescription pharmaceuticals to combat problems. These drugs have a direct mechanism with regard to preventing and reversing the growth of cardiac myocytes. I could go into detail but itā€™s not important given that using these isnā€™t the best course of action unless youā€™ve got a doc that thinks youā€™re an adequate candidate for them, as they can have nasty sides (but then again what meds donā€™t have the potential for serious adverse effects)

Sorry I havenā€™t been on here much, things have been kinda shit recently, not important though.

Anyway like 99 percent of the time when some dude says ā€œfuk bra my prolactin is high, Betta bust out some caber so I can get my dik hard and bust a nootā€ the reality is ā€œdopamine depletion, lack of lust for life in general, taking a dopamine agonist to help out with depressive symptoms and erectile dysfunction induced by nandroloneā€

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@unreal24278 your post are all ways informative and entertaining.
Sorry to hear life has thrown a few roadblocks in your way. Stiff upper lip and all that.
I hope you get it all worked out. We miss you.

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Hey brother, did you ever make it to Texas this year as was your plan?

Thank you for chiming in brother @unreal24278

It would be really good to see some studies comparing the 2 specifically with regards to their effects on the heart.

Also sorry to hear about life, its just that, life. Cant say Iā€™ve had the best year this year either but we got to make do with the cards we are dealt. My motto with regards to any situation is this, I never lose. I either win or I learn.

And remember, it shall pass. The good and the bad, both shall pass, both are temporary, nothing stays the same forever.

SB

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Something I just remembered which also strengthens the theory of DHN displacing DHT causing deca dick more so than dopamine/serotonin depletion is, when I had deca dick all those years ago, I was horny AS HELL. There was just no ā€œlinkā€ between my brain and penis. @unreal24278

If neurotransmitters were the problem, surely my libido would also be nonexistent, but since it was high it leads me to believe that the missing hormone in causing an erection was DHT.

Thoughts?

SB

This is why Masteron is so good to restore ED since its a DHT derivative.

How long did it take for your ED to reverse upon addition of masteron? @studhammer

SB

Well, it was never full on ED, I mean it worked when everything was right (ie sleep, nutrition, hydration, and of course my wifeā€™s mood). With that said, maybe a month or so

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My problem with this theory is the concept of androgen receptor saturation. In order for DHN to replace the effects of DHT, androgen receptor saturation would have to occur, thus making DHT unable to exert any effect via AR binding. There is no science/legitimate medical literature on this as it would not be ethical to pump subjects with grams of gear in hopes to acquire complete saturation.

However we do know this, when you use more gear, more androgen receptors are synthesized, and then downregulated over time which is why gains eventually taper out (body re-attains homeostasis). With new AR being synthesized, at what dose does the use of current AR overcome the new synthesis of androgen receotors leading to overall, total saturation.

DHN metabolites however, similarly to DHT, likely have potent neurosteroid activity. There are numerous effects anabolics have on the body. Vascular dysfunction, neuro sides, dopamine depletion etc.

You can still be horny and not have the ability to get an erection. Look at dudes who watch too much pornography, theyā€™ll still get horny, but even with a real life girl in front of them they wonā€™t be able to get it up, even if they want to as they are accustomed to a certain stimulation of which is now required for an erection.

In regards to androgen receptor saturation, I believe you are referring to complete saturation. However, maybe with even slight saturation of the AR by DHN in penile tissue could cause ED. I donā€™t know, just thinking out loud. We may never really know the exact cause of it, but some theories do make sense. Neurotransmitter as well as AR antagonism by Nandrolone metabolites. @unreal24278

SB

Did you continue with the NPP after the addition of Mast? If not, and it took a month or so get back to normal, it could just mean the Nandrolone cleared and the Mast didnt really do anything.

If however you ran both together, its good news, because nandrolone gives a look thats unrivalled.

SB

Yes supersaturation, when androgen concentrations build up to the extent of which more isnā€™t going to make any difference