Has anyone come across any literature around accelerated T clearance e.g. genetic predisposition to higher esterase or glucuronidation activity?
31 y/o primary complaint zero libido, decreased energy, no morning erections etc, etc. Started on Androgel x 3 months ago with increased dosing to 10 g/day as my TT, BAT, E2 continued to drop lower than pre-TRT levels. My specialist concluded I was a gel non-absorber and started me on Test E three weeks ago @ 100mg/week.
My trough TT level just before my 3rd shot came back at 6.8 nmol/L (8.4 - 28.7 nmol/L) or 195 ng/dL -- which is higher the 4.8 while I was on 10 g Androgel 1%/day. I can't even tell I am on TRT, I have had no change in libido over the last 4 months of TRT.
I've read the stickies and could provide other lab results but I really wonder if my body is just processing/eliminating T it quicker than it can stick around?
Of interest, I have a relative who is on an injectable psych med (not T, but a decanoate ester) and his clearance of the medication is very unusually high (? high esterase activity). If it weren't for the fact his nurse was giving him his injections, based on his labs they would think he wasn't receiving his meds cuz his levels never get high enough into the 'therapeutic range'.