I don’t have low SHBG, but pinning more frequently should help. You could look into something like GH instead of more AAS, but it is expensive and comes with it’s own set of sides (you probably take it already, right?).
I would stay away from orals. They seem to drop SHBG more than oils. SHBG is produced in the liver, so putting more load on the liver should lower SHBG?
Unfortunately GH can also lower SHBG. One of the possible causes of low SHBG in men (who aren’t on steroids) is acromegaly, too much growth hormone.
Singh, MENT does not lower SHBG at all. That’s about your only option that I know of for sure. It is highly androgenic but does not convert to DHT, so I don’t know if that would work for you. I know in the past the DHTs have been a trouble spot. Or at least that’s what I think I remember. If I’m wrong then forgive me.
Hyperinsulinemia does not downregulate hepatic SHBG production in obesity.
Proinflammatory cytokines and hepatic steatosis downregulate SHBG in obesity.
Monosaccharides and palmitate downregulate and oleate upregulates hepatic SHBG.
Plasma SHBG could be a biomarker of the degree of inflammation in metabolic disorders.
Sex hormone-binding globulin (SHBG) is produced and secreted by the liver into the bloodstream where it binds sex steroids and regulates their bioavailability. Traditionally, body mass index (BMI) was thought to be the major determinant of SHBG concentrations and hyperinsulinemia the main cause for low SHBG levels found in obesity. However, no mechanisms have ever been described. Emerging evidence now shows that liver fat content rather than BMI is a strong determinant of circulating SHBG. In this review we discuss evidence demonstrating that insulin might not regulate SHBG production, describe putative molecular mechanisms by which proinflammatory cytokines downregulate SHBG, and comment on recent findings suggesting dietary SHBG regulation. Finally, clinical implications of all of these findings and future perspectives are discussed.
Dunno about AAS, but a SERM should raise your SHBG, at least they do when off PEDs. Maybe some Nolva thrown in would raise it? Or, do test only blasts? IDK I’m in the same boat as you. My SHBG is 20nmol but goes to single digits if I add in Var or LGD
Hi @Singhbuilder when I was naddy my shgb was 29 and post 2 years of strict TRT my shgb was 16. Even when I blasted 300, 400 and even 500mg/wk of Tcyp or TE my shgb held at 16. Only when I added anavar and or winny did my shgb tank to 6 and lipids tanked to death numbers. The gains were not equal to the price of bad bloods. Lipids tanked E2 was over range by 3X, I am done with AAS there is nothing there for me. Good luck. YMMV
Does not and can not convert to DHT. It’s still very androgenic though. Granted the way that we measure that is pretty stupid (we are not rats) but the numbers are pretty big nonetheless. Look up the anabolic:androgenic rating and be blown away.
In terms of chronic inflammation one could start with CRP. However, this is a whole field in and of itself which is why most Providers won’t try to measure all the cytokines but instead recommend diet and exercise interventions to reduce BF and improve insulin sensitivity. Here’s more on the cytokines:
I am not smart enough to recommend anything. But for me, I am done with oral AAS’s, GH, and insulin. Over the last two years, I have experimented and found the gains were not worth the bloods. YMMV My future blast will be T only.
@unreal24278 So where is the upside in taking AAS’s if you want to live a long time? I don’t see one. In my limited experience with AAS’s what I gained was not worth the hit to my bloods. Sorry boys I am done playing the AAS game. I will just stick to TRT and blasting twice a year.