what are your lifts? 5x10, in my opinion, can be good for hypertrophy. it really depends where you are. I have been using the Wendler 5/3/1, and 5x10 is the suggested accessory template for hypertrophy. I tried this, but felt that if I was using a weight that I could lift for 5x10, I was short changing myself with regards to the weight I could use (and subsequent muscle trauma and growth). I instead opted to do my accessories (the lifts you do other than your main lift of the day e.g. deadlift/military press/benchpress/squat) in a 2-3 warmup set fashion, then a rep max set.
what I just described, albeit somewhat awkwardly, is called “ramping”. you pick a weight to warm up at. then you increase the poundage and do another set. you can go up in weight something like 2-3 times, until you come to your heaviest set for that exercise, which is called your “top set” or “work set”. you do as many reps as possible at this weight.
here’s an easy example. for something like DB benchpress, you might pick 45 pounds to start, and do 10 reps. seems easy enough, so you go up 20 pounds to 65 pounds. you do 8 reps at that weight. by this time you will be able to gauge how much you have left in the tank. you decide to go up to 85 pounds. you get into position, and complete 5 reps, and almost get the 6th rep up. some would say try and get another set of 85 pound presses.
hope that helped or gave you something to think about with your training.