ft3=3 was below mid range 3.25
Doctors and ‘normal’ thyroid labs are a problem.
Unknown. You can try and see.
T lab ranges can be age adjusted.
Are you saying this is low enough to indicate a problem?
I’ve been taking anastrozole since that old post from June. It’s made a big difference in E2 and prolactin. My subsequent posts have the updated lab work.
TT and FT going down as LH/FSH increases. Looks very strongly like primary hypogonadism.
Is FT3 a problem? Not by looking at your oral body temperatures.
Looks to me as if TT is flat going as far back as 2/17/15 (was 495ng/dL [250-1100]). However, in that same test, FT was 59.2pg/mL [35.0-155.0]. The reference interval is much higher, so I’m not sure how this equates to current numbers.
According to Mayo Clinic, primary hypogonadism would be caused by:
- Genetic causes (eg, Klinefelter syndrome, XX males)
- Developmental causes (eg, testicular maldescent)
- Testicular trauma or ischemia (eg, testicular torsion, surgical mishap during hernia operations)
- Infections (eg, mumps)
- Autoimmune diseases (eg, autoimmune polyglandular endocrine failure)
- Metabolic disorders (eg, hemochromatosis, liver failure)
- Orchidectomy
I would rule out 1, 2, 4 and 7. 3 and 6 seem most likely.
#3 - Had a left epididymectomy several years ago, and a revision a year later. Could possibly have resulted in trauma to the testicle, but I’m not aware of it if it did.
#6 - Fatty liver resulting in high AST/ALT? Perhaps some aspect of metabolic syndrome?
EDIT: Been reading about the (high) correlation between low T and metabolic syndrome, which includes fatty liver disease. It occurs to me that at the time of my 7/11/17 blood test, I had been eating very strictly low carb for about a month and lost nearly 10 lbs. After that, have been eating more carbs and weight loss has stopped. Could the spike in TT in July be due to the weight loss?
Updated lab result history. As of 7/12/18:
| Range | Units | 7/12/2018 | 2/23/2018 | 8/4/2017 | 7/11/2017 | 6/14/2017 | 5/17/2017 | |
|---|---|---|---|---|---|---|---|---|
| T, Serum | 264-916 | ng/dL | 581 | 663 | 496 | |||
| " | 348-1197 | ng/dL | 566 | 504 | ||||
| Free T (Direct) | 7.2-24.0 | pg/mL | 17.8 | 21.7 | 11.5 | 13.6 | 12.1 | |
| Estradiol | 7.6-42.6 | pg/mL | 25.1 | 28.1 | 17.0 | 27.0 | 41.5 | |
| " (Sensitive) | 8.0-35.0 | pg/mL | 15.3 | 24.9 | ||||
| Prolactin | 4.0-15.2 | ng/mL | 8.9 | 0.6 | 10.9 | 16.1 | 18.9 | 21.5 |
| LH | 1.7-8.6 | mIU/mL | 7.4 | 11.8 | 8.2 | 7.0 | ||
| FSH | 1.5-12.4 | mIU/mL | 10.2 | 13.3 | 10.0 | 8.6 | ||
| DHEA-S | 71.6-375.4 | ug/dL | 166.5 | 196.7 | 175.5 | 143.4 | 181.7 | |
| PSA, Serum | 0.0-4.0 | ng/mL | 1.2 | 1.0 | 1.0 | 0.9 | 0.8 |
Current dosing:
anastrozole - 0.2mg E2D
cabergoline - 0.08mg E3D