To eval your CV health you need to know if there is an inflammatory process in the arteries, IE endothelial dysfunction. The best indicators are blood pressure and labwork for homocysteine which is a CV specific inflammatory marker.
DHEA 25mg depending on labs for DHEA-S, do not do DHEA lab work.
high potency B-complex multi-vits with no iron, trace elements including iodine+selenium
5000iu Vit-D3 per day
natural source vitamin E
If you get leg or foot cramps, you are magnesium deficient. Magnesium also critical for tone of arterial muscles.
Are you taking a statin drug to lower cholesterol and if yes, do you have sore muscles or chronic low level cough? If yes again, can be statin induced CoQ10 deficiency which can be resolved with 50-100mg ubiquinol, not ubiquinone, form of CoQ10.
If you inject T into a vein, you will get a cough and ticking of lungs from the oil. Seems quite harmless and resolves in 15-30 minutes.
TRT with proper E2 management is CV friendly and a few years ago, a retrospective study of VA patient records showed that TRT guys had ~30% less heart attacks, clots/thrombosis and strokes that comparables not on TRT. That is quite remarkable as we know that TRT is very mismanaged in the VA.
Your TT=400 lab results were half way between weekly injections or at the end of 7 days?
Injections should be twice a week, SC/SQ, not IM to get steady levels. Then anastrozole should be used to keep E2 near 22pg/ml which seems optimal for most guys, but some are exceptions and are wired to do better with more E2.
Ask do do this:
- 80mg T self injected SQ twice a week with #29 1/2" 0.5ml insulin syringes
- 0.5mg anastrozole at time of injections
- 250iu hCG SC EOD to preserve testes and support pregnenolone production
Target is FT at top of range, adjust dose proportionately.
Lets say that your get FT=35 and top of range is 30 and you get E2=28 and target is E2=22. You would change anastrozole by two factors. So new dose = old dose X 30/35 X 28/22, new dose = 0.5mg X 30/35 x 28/22 = .55mg. To get arbitrary doses, dissolve anastrozole in vodka 1mg/ml and dispense by the drop or by volume. A dropper bottle with 1/4ml markings is suggested.
The above shows how you can adjust anastrozole dose with T dose changes at the same time. Do not expect your doctor to understand this.
TRT improves the integrity of tissues and collagen, which also strengthens the lungs.
Please read the stickies found here: About the T Replacement Category
- advice for new guys
- things that damage your hormones
- protocol for injections
- finding a TRT doc
Evaluate your overall thyroid function by checking oral body temperatures as per the thyroid basics sticky. Thyroid hormone fT3 is what gets the job done and it regulates mitochondrial activity, the source of ATP which is the universal currency of cellular energy. This is part of the body’s temperature control loop. This can get messed up if you are iodine deficient. In many countries, you need to be using iodized salt. Other countries add iodine to dairy or bread.