T Nation

4 Wks In, Never Had Sleep or Breathing Issues. Now Have Both


At around week 3 of 175 weekly, (Test-E 75 ml e3d) my breathing become very labored.

Felt like I had about half the lung capacity as normal. Began sleeping an extra 2 hours early each night and still felt exhausted in the morning. Cardio is painful and lungs burn quickly and throughout the day each breath is difficult to pull in and feel constantly out of breath.

I didn’t connect the two and thought it was my hormone profile becoming accustomed. But after much research it looks as if HRT can often make create or cause to surface unknown sleep apnea cases.

Has anyone dealt with this before? Would the suggestion be to get give blood and or/ try other medications to thin blood or would this not be causing the weak breath? And/or dealing with it and looking into CPAP machine/sleep study or possibly drop weekly dose? Not using any AI and was going to wait until week six to get blood drawn but may go now. This doesn’t seem to be an e2 or thyroid issue as I exhibit none of the other symptoms and more a breath issue


Nobody can handle that much testosterone without an AI, you need to take action now. It will only get worse as with each injection E2 will climb higher and higher. Inject 50mg twice weekly is a great starting point, most who start out on high dosages eventually learn to inject smaller dosages.

You also require proper labs to tailor a protocol for you, usually your SHBG value will largely determine how many shots you require in a given week. Your doctor should order a sleep study regardless, it’s a requirement if a guy wants to remain on TRT.


Easily can be high E2 and that is not a slow process. E2 would be up in a few days. The effects of E2 can take a while to surface because gene expression changes take time and changes caused by that takes time.

Can you check resting BP and pulse?
Do not get dehydrated as that thickens your blood.
Baby aspirin until you find out more, it helps blood flow.

See if you can get E2 tested now and CBC+hematocrit

On TRT labs: - minimal

We can provide more assistance when you provide more info about you - context.

Please read the stickies found here: About the T Replacement Category

  • advice for new guys - need more info about you
  • things that damage your hormones
  • protocol for injections
  • finding a TRT doc

Evaluate your overall thyroid function by checking oral body temperatures as per the thyroid basics sticky. Thyroid hormone fT3 is what gets the job done and it regulates mitochondrial activity, the source of ATP which is the universal currency of cellular energy. This is part of the body’s temperature control loop. This can get messed up if you are iodine deficient. In many countries, you need to be using iodized salt. Other countries add iodine to dairy or bread.

KSman is simply a regular member on this site. Nothing more other than highly active.

I can be a bit abrupt in my replies and recommendations. I have a lot of ground to cover as this forum has become much more active in the last two years. I can’t follow threads that go deep over time. You need to respond to all of my points and requests as soon as possible before you fall off of my radar. The worse problems are guys who ignore issues re thyroid, body temperatures, history of iodized salt. Please do not piss people off saying that lab results are normal, we need lab number and ranges.

The value that you get out of this process and forum depends on your effort and performance. The bulk of your learning is reading/studying the suggested stickies.


I understand and thank you very much for the detailed reply. So as I am understanding it, I am quite likely to have jacked up my e2 numbers by overshooting my numbers at the start.

For my next step, I will take your advice and look into the thyroid threads and checking oral body temperatures. As well as begin a baby aspirin per day, half a grape fruit, stay hydrated and check BP throughout the day. As well as get a blood test ASAP making sure to include CBC and hematocrit numbers.

I think I will try dropping to 125-150 weekly? As it seems I haven’t felt any positive effects this far, so wouldn’t want to drop too low, though the test ether may not have fully binded yet at only week 4.

Thank you again.


OK that is interesting. I suppose I can always increase the dosage over time to desired levels rather than battle side effects from too high a dose. I will get on this ASAP. Thank you.