hCG 200iu ED to too much
250iu hCG SC/SQ EOD is more than enough
Please change hCG dose, try 250iu SC/SQ EOD.
For a few guys, 250iu hCG SC EOD is too much.
hCG has a longer half-life and EOD is fine.
High dose hCG can lead to high amounts of T–>E2 inside the testes and high SERM E2 levels. Note that anastrozole cannot manage T–>E2 inside the testes. Then sometimes we see higher doses of anastrozole simply not working. Do not expect to find doctors who understand this or understand why.
We normally see guys needing 1mg/week anastrozole per 100mg T per week. A few are over-responders who crash E2 on that and they need 1/4th that expected dose.
TSH does not tell the whole thyroid story. Self-eval thyroid function via last paragraph in this post.
FSH is high. If you test FSH one time on TRT you should get FSH–>zero, otherwise testicular cancer is suspected [not rare]. FSH secreting pituitary adinomas are rare.
Your TT and FT suggest high SHBG that is made in the liver to clear sex hormones. SHBG can be elevated from high E2 which you do have. With lower E2, SHBG should decline slowly.
You might consider having a fertility test if you have not made any babies already.
You can inject T cyp SC/SQ and get smoother T levels and avoid decades of muscle damage. Use #29 1/2" 0.5ml insulin syringe. Pinch up skin over upper leg and inject into end of fold parallel to tissue underneath. After injecting, press finger on injection site for 10-15 seconds to allow tissues to stick together, preventing leakage and bleed bruises.
Please read the stickies found here: About the T Replacement Category - #2 by KSman
- advice for new guys
- things that damage your hormones
- protocol for injections
- finding a TRT doc
Evaluate your overall thyroid function by checking oral body temperatures as per the thyroid basics sticky. Thyroid hormone fT3 is what gets the job done and it regulates mitochondrial activity, the source of ATP which is the universal currency of cellular energy. This is part of the body’s temperature control loop. This can get messed up if you are iodine deficient. In many countries, you need to be using iodized salt. Other countries add iodine to dairy or bread.