Pregnenolone is created from cholesterol and can be converted to DHEA and/or Progesterone. I have plenty of cholesterol, so if my pregnenolone were low, i’d look at supplementation. From what I’ve read, taking it orally can be a bit of crap shoot. It’s not absorbed very well. Micronized is supposed to be better. Transdermal would be even better. I haven’t looked around for transdermals. I’ll probably end up making my own if it comes to that. There was a popular DHEA and Pregnenolone transdermal, but not sure they make it anymore or if they would be considered a competitor to this fabulous site.
Once I had pregnenolone where I wanted it, I would look at DHEA and Progesterone. These are two different loops if you will and should be treated separately to a point. Since you seem to have some thyroid issues to sort, you might want to start with the progesterone side.
If Progesterone is low, supplement. Transdermals are readily available. If Progesterone looks good, move on to cortisol.
If cortisol is low, move on to thyroid tests. Not sure what the treatment is for low cortisol. it’s high, treat it. I can’t remember where I read this or if I am remembering this correctly, but I don’t believe you want to take any kind of stimulant if cortisol is screwed up. I believe this would include SSRIs. If it’s high or low, you could sniff around and see if increasing dopamine might help.
If pregnenolone, progesterone, and cortisol all look good, you could move on the the DHEA side.
DHEA side -
At some point E2 should be checked and treated as necessary.
If DHEA is low, supplement directly (transdermal better) or try Magnesium Gel. If DHEA is good, move on the SHBG.
If SHBG is high treat. If it looks good, move on to T and recheck E2.
If pregnenolone and DHEA both look good but T is still not that great, your really just left with looking E2, LH, and maybe DHT. Quite frankly, I’m not sure why someone would be concerned with DHT unless they were losing their hair or had prostate issues, but I haven’t gotten that far.
If you can’t tell, I’m just some anonymous joe on a message board. I am not a doctor or in the medical industry at all. I have my own issues and this is just how I would go about things. There are probably short-cuts and/or better routes to take, but I need to simplify things for my own understanding and take them one step at a time. Hopefully some of the more educated members will provide more feedback.[/quote]
This is terrific. Thank you. I will have to review this and continue to read the stickies/look at other resources online.