T Nation

27 y/o. Just Started TRT



I am 27 yrs old / 6’1" / 230lbs and after 3-4 years of clomid/ aromasin therpay for low testerone (238-290), my levels fell again to 267ng/dl and my doctor started me on trt with 200mg test cyp injected every two weeks. Of course, more frequent injections will be ideal once I get tested and we establish the best dose. For now I am following the protocol since he wishes to re-draw 7 days after my third injection.

That is part of my question. I understand the basics of the half lives of the drug but, wouldnt every 14 days suggest there is zero of the drug in my system? This wouldn’t necessarily equate to 0 ng/dl test levels correct?

I’m also curious why the same dose can give two different men vastly different readings if they got tested the same time after injection?

I am currently not running any AI’s as even on clomid only therapy my estrogen never elevated beyond the acceptable range for men.

Thank you for any help you can offer.


WHAT you should seek:

  • self inject 50mg T twice a week with #29 1/2" 0.5ml insulin syringes, SC/SQ not IM
  • 0.5mg anastrozole at time of injections to manage E2 and do more reading…
  • 250iu hCG SC/SQ EOD to preserve testes and fertility otherwise at major risk

Most doctors are clueless about make hormone care. You need to become knowledgeable so you can manage this. Passive does not work.

Men can metabolize T faster/slower than others.
Total T is: FT + albumin+T + SHBG+T
E2 levels vary for numerous reasons, creating more/less SHBG+T which is not bio-available but affects TT lab results.

After two weeks, FT. Bio-T have crashed, but lingering E2 will create adverse E2:T levels and that coupled with the physiological effects of low and dropping T typically makes guys feel worse off then pre-TRT.

Women on HRT get daily hormone delivery and your doc? Doctors do not need to have any depth of critical though or deductive reasoning to get medical degrees.

Please report what your dosing was for clomid and aromasin. Do you have TT, FT E2, LH/FSH from that?

E2 acceptable range: Lab normal ranges should not be construed to be healthy or optimal. Guys on TRT with high-normal TT and FT with E2>35 can typically feel horrible. Getting near E2=22pg/ml 0- 80pmol/L is for most, optimal energy, libido, calmness, mood, fat levels and fat patterns.

Lab ranges are statistical normal curve derived:

So most people/samples normally fall withing 2 or 3 standard deviations.
But the medical community takes “normal” a meaning healthy when this clearly is not the case. When these curves are created from sample groups of people, the samples include many individuals who are not feeling well. Alternatively, the medical community then accepts that only 0.3% can be unwell. Best example is TSH where a 11:1 ratio is “normal” when many are really suffering.

Please read the stickies found here: About the T Replacement Category

  • advice for new guys
  • things that damage your hormones
  • protocol for injections
  • finding a TRT doc

Evaluate your overall thyroid function by checking oral body temperatures as per the thyroid basics sticky. Thyroid hormone fT3 is what gets the job done and it regulates mitochondrial activity, the source of ATP which is the universal currency of cellular energy. This is part of the body’s temperature control loop. This can get messed up if you are iodine deficient. In many countries, you need to be using iodized salt. Other countries add iodine to dairy or bread.


I tried 3 routes. Clomid only (25mg daily) , Aromasin only (25mg daily) and a combination of the two. This was a hormone therapy alternative while my wife and I were working to get pregnant. Since my son was born, fertility is no longer a huge priority but I def agree with preserving it as much as possible.

I gave the results to my new doc but generally speaking, pre-clomid and aromasin therapy my levels were 230-300 @24-25yrs old. 6 weeks post clomid only I was at 788 with estrogen in the “normal range” of what the lab said and bio available t has always been toward the upper range of normal. When I did the clomid/ aromasin combo bio-t was actually outside of the normal range but total t did not change much and of course estrogen went down but remained inside the “normal range”

I agree that there will be alot of estrogen sides from e2w dosing. Id prefer 1-2x per week minimum. I am supposed to get blood work drawn 7 days post 3rd injection. Would the below scenarios produce similar results?

*scenario 1: Admin 1ml (200mg) friday. test 7 days later.

*scenario 2: Admin .5ml (100mg) on mon and fri. test 7 days post friday inj.