E2 [estradiol] is way too high, many labs have ranges that have much lower upper limits.
High E2 is negative feedback reducing LH & FSH and T goes down.
E2 can be reduced with 1/4mg anastrozole twice a week, do reading…
FT not tested, typical for UK.
If SHBG tested, calculated FT can be provided.
FT–>E2 rates are proportional to FT levels.
Assuming that FT is lower, your high E2 implies low E2 clearance rates in the liver. Labs for AST, ALT, CK would be useful.
Some medications, Rx and OTC can interfere with E2 clearance by competing for the responsible enzyme pathways.
Many in UK are iodine deficient and in UK, you are expected to get most of your iodine from dairy foods and sea food. Your low cholesterol levels suggest low dairy intake. Iodized salt is available there, but most shops do not have it.
Low HDL suggests low B vitamins.
Your Vit-D is low and a serous problem. Vit-D3 is slowly converted to Vit-D25 that is a true and essential hormone.
Find high potency B-complex multi-vits that have trace elements including 150mcg iodine and 150-200mcg selenium.
Take 5,000iu Vit-D3 every day, 25,000iu for first 5 days.
Take with a meal that has more fats and low fiber.
Look for tiny oil filled gel caps. We find 5,000iu easily in USA.
Let your total cholesterol increase, 180 is ideal. Cholesterol is the foundation for creating all of your steroid hormones.
TSH should be closer to 1.0
fT3 appears low to me, but ~OK with the range used there.
fT4 same as above
Ranges may be lower there reflecting lower iodine status in UK population.
Check overall thyroid function via oral body temps, see below.
This is very important. Purchase a thermometer if needed.
With a low fat diet, you may be EFA deficient. Fish oil, nuts, flax seed meal/oil can address that. Do not take these with high fiber meals!
- EFAs and health fats as needed
- increase cholesterol
- multi-vit as specified above
- Vit-D3 as specified above
- iodized salt
- liver specific labs and medication review
- anastrozole as above to lower E2 if you can get that, then E2 labs in 4 weeks
Please read the stickies found here: About the T Replacement Category
- advice for new guys - need more info about you
- things that damage your hormones
- protocol for injections
- finding a TRT doc
Evaluate your overall thyroid function by checking oral body temperatures as per the thyroid basics sticky. Thyroid hormone fT3 is what gets the job done and it regulates mitochondrial activity, the source of ATP which is the universal currency of cellular energy. This is part of the body’s temperature control loop. This can get messed up if you are iodine deficient. In many countries, you need to be using iodized salt. Other countries add iodine to dairy or bread.
KSman is simply a regular member on this site. Nothing more other than highly active.
I can be a bit abrupt in my replies and recommendations. I have a lot of ground to cover as this forum has become much more active in the last two years. I can’t follow threads that go deep over time. You need to respond to all of my points and requests as soon as possible before you fall off of my radar. The worse problems are guys who ignore issues re thyroid, body temperatures, history of iodized salt. Please do not piss people off saying that lab results are normal, we need lab number and ranges.
The value that you get out of this process and forum depends on your effort and performance. The bulk of your learning is reading/studying the suggested stickies.