Quick update on my situation, i have had a very extensive set of labs done plus 24 hour urine analysis. Apologies for the length of post as many labs. I will highlight the ones which are of greatest concern to me, would appreciate your thoughts on these.
PS. Was done by a French Lab have tired to translate most words but may have missed some.
Haemoglobin 14.4 g/dL 13.5 - 18.0
Haematocrit 41.0 % 40-54
RBC 4.57 10*6/uL 4.5-5.9
MCV 90 fL 80-95
MCHC 35 g/dL RBC 31-36
MCH 32 pg/cell 27-32
Vitamin B12 481 ng/L 300-835
Erythrocytic folate 471 ug/L 140-628
Ferratin 61 ug/L 50-240
Glucose 84 mg/dl 60-110
Insulin 79 pmol/L 21-153
Index HOMA 2.34 0.74-2.26
Index Quicki 0.34 0.35 - 0.41
This is particularly worrying as it represents a high risk of insulin resistance and eventually developing type 2 diabetes. However i already eat a very strict and clean diet so this is confusing. What else can cause this. PS. diabetes does not run in my family.
Triglycerides 242 mg/dL 30-170
Total Cholesterol 184 mg/dL 120-200
HDL Cholesterol 52 mg/dl 120-200
LDL Cholesterol 84 mg/dL 0-114
Cholesterol/ HDL-C 3.54 2.8 -4.97
Again this is a worrying score for cholesterol, my Cholesterol numbers have also been getting worse alongside a rise in TSH. It is strange because the more i have cleaned up my diet the worse my readings have been?
TSH 3.48 mU/L 0.3 - 4.5 (was 1.7 mu/L Last year)
T3 Free 6.06 pmol/L 3.23-6.47
T4 Free 13.21 pmol/L 9.03 -23.22
ab to thyroglobulin <15 kU/L <60 Neg
Anti-TPO <28 kU/L <60 Neg
Thyroid Urine test
T3 0.17 ug/L
T3 757 pmol/24H 800-2500
T4 0.43 ug/L
T4 1600 pmol/24H 550-3160
In the blood analysis my TSH has been steadily rising over the last year. However the part i am confused about is my Free T3 is top of the range where as my T4 is bottom. My understanding is T3 is converted to T4 so how can one be high and the other low? This also doesnt explain my hypothyroid symptoms plus low temperatures? Could RT3 be a factor.
Also the 24 hour urine sample had both T3 below range, with T4 midrange, why would these be different from the blood analysis?
You where also correct i am indeed iodine deficient
Idoine 49 ug/L
Iodine 142 ug/24H 170-280
i am planning on buying Lugols 12% solution. How would one dose this? Also how does one know when they have achieved saturation and can drop back to a maintenance dose
Cortisol (8h) 7.8 ug/dL 7-25
Transcortin 44 mg/L 20-50
Cortisol free (8 AM) 3.5 ug/L 10-30
FSH 5.5 IU/L 2-15
Estradiol 41 ng/L <30
Estrone 20 ng/L 10-60
Progesterone 0.45 ug/L 0-1
Testosterone 500 ng/dL 300-1000
Testosterone free 1.82 ng/dL 0.5 - 2.8
SHBG 33 nmol/L 20-55
DHEA-S 303 ug/L 200-610
Pregnenolone 1.37 ug/L 1.17-7.72
IGF-1 346 ug/L 190-490
IGFBP-3 4.08 mg/L 2.96-4.96
IGFBP-3/IGF-1 3.11 mol/mol 0-4.5
17-OH Steroids Chromatography
Tetrahydrodeoxycortisol 0.44 mg/24H 0.05-2.30
Tetrahydrocortison 1.39 mg/24H 2.40-5.20
Tetrahydrocortisol 0.17 mg/24H 1.50-3.30
Total 17-OH Steroids 2.00 mg/24H 6.10-11.70
Aldosterone 9.1 ug/24H 2.8-30.0
Growth Horome 25.69 ng/24H 0-10
6-sulfatoxy-Melatonin 28.8 ug/24H 15.6 - 58.1
My thoughts are that iodine deficiency has contributed to sub-clinical hypothyroidism, which could in turn effect metabolic functions. This could explain high triglycerides.
I am not well read in adrenal fatigue however my cortisol levels are low alongside 17-OH Steroids which could suggest some form of malfunction in the adrenal axis.
I am confused as to why my GH is double the top range, as i deffinatly do not feel the benefits attributed to high GH. (Energy, fat loss, lean muscle gain). Could be body be over compensating to make up for a lack in other hormones.
My Testosterone has risen only slightly yet Estrogen which was always coming back low is now high? I wonder could this be due to a lack of the ultra-sensitive test in the UK which perhaps they have used for my new labs?
The insulin resistance is a big concern for me and could explain why i struggle to gain muscle and put fat on easy despite having strict diet and going to gym 5x a week.
Again apologies for the long post, would appreciate anyones thoughts on these labs.