21 Y/O with Progressively Worsening Test Levels

Those labs were with or without thyroid meds?
fT3 was mid-range and should support good body temperatures.
Should be >= 97.7 when you wake up and reach 98.6 mid-afternoon

fT3 is the only active thyroid hormone. There is no receptor for T4. T4 is a reservoir for T4–>T3 conversion. fT3 is part of the body’s temperature control loop, controlling your energy and metabolic rate.

Standard recommendation:
self inject 50mg T twice a week, subq not IM, #29 1/2" 0.5ml insulin syringe
250 iu hCG subq EOD, above syringe or #31 5/16"
0.5mg anastrozole at time of injections

Some are anastrozole over-responders who need to take 1/8th mg twice a week.

E2 management needs steady doses of T and anastrozole. You mostly can’t be making dose changes based simply how you feel one day VS the next.

I might be able to provide better response, but I am confused by time line and lack of labs along the way and/or format of lab data.

When fT3 is good with low body temperatures we suspect elevated rT3 and stress issues.

You have not discussed if you had been using iodized salt - history of that please.

In the future, put lab data in list format with ranges, please not inside prose.

What iodine supplement?
Have you been getting selenium in vitamin pills?

What estrogen problems did hCG create?
Labs to validate that?

Thyroid meds made you feel hyper?
Did you see high body temperatures?
You were jittery or like too much caffeine?
Sleep affected?


Please read the stickies found here: About the T Replacement Category - #2 by KSman

  • advice for new guys - need more info about you
  • things that damage your hormones
  • protocol for injections
  • finding a TRT doc

Evaluate your overall thyroid function by checking oral body temperatures as per the thyroid basics sticky. Thyroid hormone fT3 is what gets the job done and it regulates mitochondrial activity, the source of ATP which is the universal currency of cellular energy. This is part of the body’s temperature control loop. This can get messed up if you are iodine deficient. In many countries, you need to be using iodized salt. Other countries add iodine to dairy or bread.

KSman is simply a regular member on this site. Nothing more other than highly active.

I can be a bit abrupt in my replies and recommendations. I have a lot of ground to cover as this forum has become much more active in the last two years. I can’t follow threads that go deep over time. You need to respond to all of my points and requests as soon as possible before you fall off of my radar. The worse problems are guys who ignore issues re Thyroid, body temperatures, history of iodized salt. Please do not piss people off saying that lab results are normal, we need lab numbers and ranges.

The value that you get out of this process and forum depends on your effort and performance. The bulk of your learning is reading/studying the suggested stickies.