That is too much letrozole. E2 will be very low and that has its own problems. Your "no effects" means that the effects of that are not too severe. [or you do not notice]
Would that mean I can continue on that dosage until I get any side effects?
Your knowledge and command of writing is amazing.
Thank the armodafinil for that!
How tall are you?
When did you stop getting taller?
Did you start growing taller early or late?
177 cm tall, stopped growing somewhere around 2015-2016. I'm not sure at what age I started getting taller but I'm sure it was normal as my friends were no different.
On Tamoxifen you should be getting LH/FSH quite soon to see how the hypothalamus and pituitary are responding.
It's been 20 days since I started it, when should I test LH FSH? 60 day mark? Also, what if my LH and FSH don't go up? Would that make a pituitary tumor likely?
Please eval overall thyroid function via oral body temperature as requested below. You might also be feeling cold easily, dry skin and have sparse outer eyebrows.
Had exactly this before I started letrozole. Letrozole seems to raise my body temperature slightly. I'm not sure but it could be the tamoxifen as well.
Really do need lab ranges, you can edit your post to add the ranges.
Haemoglobin: 14.5 gm/dl
12 - 18
Total Leucocyte Count: 6800 /cumm
4000 - 10000
Total Erythrocyte Count: 6.17 million/cumm HIGH
4.0 - 5.9
34 - 54
Total Platelet Count: 2.94 10,000/cumm
1.5 - 4.5
Red Cell Distribution Width: 15.3 %
12 - 17
MCV: 79.7 fl LOW
82 - 100
MCH: 23.5 Pg LOW
27 - 32
MCHC: 29.5 %
28 - 40
Neutrophils: 60 %
30 - 70
Lymphocytes: 32 %
15 - 40
Eosinophils: 06 %
0 - 6
Basophils: 00 %
0 - 1
Monocytes: 02 %
2 - 10
LFT results from 3 days ago:
Total Bilirubin: 0.94 mg/dl
Direct Bilirubin: 0.17 mg/dl
Indirect Bilirubin: 0.77 mg/dl HIGH
0.2 - 0.7
Aspartate Transaminase (AST/SGOT): 51.1 U/L HIGH
Serum Alanine Transaminase (ALT/SGPT): 46.2 U/L HIGH
5 - 40
Alkaline Phosphatase: 196.0 IU/L
70 - 300
Total Protein: 7.2 gm/dl
6.2 - 8.4
Albumin: 4 gm/dl
3.5 - 5.1
Globulin: 3.2 gm/dl
2.3 - 3.6
I did show the elevated AST, ALT and the unconjugated bilirubin values to my doctor but he said it isn't significant and I shouldn't be concerned about it.
Evaluate your overall thyroid function by checking oral body temperatures as per the thyroid basics sticky
Location: Where are you? Affects how iodine is made available as well as diagnostic and treatment options.
A few questions if you wouldn't mind answering:
- Would aromatase inhibition increase 5-alpha-reductase activity and hence increase levels of DHT?
- What if I use letrozole at this dosage for longer periods of time like 6 months if I don't get any side effects?
- What exactly do you think could be my problem? What genetic defect causes these symptoms? I have an intact sense of smell.
- If the tamoxifen and letrozole do in fact restart my HPTA somehow, will the effect remain after I stop taking them?
Thank you so much for the advice!