I didn't even know accutane was still on the market. Anyway, I took it when I was 19-20 (9 months total?) throughout the football offseason. I personally did not notice any side effects with respect to athletic activity, and we did some pretty heavy lifting. The only thing I remember was my lips constantly drying out, so I had to keep some chapstick or the like on hand at all times, including using it at night sometimes.
As for the depression issue, accutane improved my mood considerably because for the first time in many years my acne was finally getting under control. The other nice thing about accutane is that after you are done, you are hopefully rid of acne forever, or can get by using minor topical creams.